ZNF554

Across TCGA cell cohorts, ZNF554 mutation is significantly associated with the mutation status of many other genes, with 1,951 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF554-associated genes across cancer lineages are JPH4, C9orf131, and TMEM185B. Each is linked with ZNF554 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF554-to-partner and partner-to-ZNF554 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JPH4 grouped by ZNF554-low versus ZNF554-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF554→partner) and Y-score (partner→ZNF554) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	JPH4 →	+4.824	+5.392	.004	.004	1	3
BLOOD_Leukemia	C9orf131 →	+4.000	+5.050	.008	.008	1	3
STOMACH	TMEM185B →	+4.807	+4.807	.008	.008	1	3
LARGE_INTESTINE	FES →	+2.159	+3.807	.007	.007	1	3
LARGE_INTESTINE	PRKD1 →	+2.159	+3.807	.007	.007	1	3
BLOOD_Lymphoma	PPP4R3A →	+5.247	+4.429	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,951 associations by consensus.

JPH4 by ZNF554 expression — SKIN

Explore this box plot interactively →