ZNF552

Across TCGA patient cohorts, ZNF552 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF552-associated genes across cancer lineages are FOXO3a_pS318_S321, EGFR_pY1068, and eIF4E. Each is linked with ZNF552 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF552-to-partner and partner-to-ZNF552 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by ZNF552-low versus ZNF552-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF552→partner) and Y-score (partner→ZNF552) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.113	-2.212	.021	.010	3	2
UCEC	EGFR_pY1068 →	-0.240	-2.000	.014	.010	3	1
UCEC	eIF4E →	+0.176	+2.000	.033	.010	3	1
UCEC	FASN →	+0.359	+1.584	.020	.036	3	1
UCEC	GSK-3_pS9 →	-0.425	-1.874	.007	.049	3	1
UCEC	IGFBP2 →	-0.848	-2.000	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

FOXO3a_pS318_S321 by ZNF552 expression — UCEC

Explore this box plot interactively →