ZNF549

Across TCGA patient cohorts, ZNF549 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF549-associated genes across cancer lineages are ASNS, Cyclin-B1, and FASN. Each is linked with ZNF549 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF549-to-partner and partner-to-ZNF549 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ZNF549-low versus ZNF549-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF549→partner) and Y-score (partner→ZNF549) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.290	+1.874	.016	.049	3	4
UCEC	Cyclin-B1 →	+0.812	+3.906	<.001	<.001	3	4
COAD	FASN →	+0.666	+3.178	<.001	.010	3	3
UCEC	MEK1 →	+0.343	+1.584	.005	.009	3	3
UCEC	PCNA →	+0.324	+2.201	<.001	<.001	3	3
UCEC	C-Raf →	+0.189	+1.502	<.001	.027	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

ASNS by ZNF549 expression — UCEC

Explore this box plot interactively →