ZNF549

Across TCGA cell cohorts, ZNF549 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF549-associated genes across cancer lineages are MEIKIN, C14orf177, and APOL4. Each is linked with ZNF549 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF549-to-partner and partner-to-ZNF549 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEIKIN grouped by ZNF549-low versus ZNF549-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF549→partner) and Y-score (partner→ZNF549) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MEIKIN →	+0.212	+5.169	<.001	.005	3	1
BLOOD_Leukemia	C14orf177 →	+0.076	+4.922	<.001	.009	3	1
LARGE_INTESTINE	APOL4 →	+0.843	+3.369	<.001	.005	3	1
LARGE_INTESTINE	LAX1 →	+0.097	+3.228	<.001	.009	3	1
LARGE_INTESTINE	OR10W1 →	+0.009	+3.240	<.001	.004	3	1
LARGE_INTESTINE	TAFA1 →	+0.205	+2.688	.004	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MEIKIN by ZNF549 expression — BREAST

Explore this box plot interactively →