Across TCGA pan-cancer cohorts, ZNF548 mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated ZNF548 data layer compared with 25 for mass-spec protein and 5 for mutation status.
The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ZNF548 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF548 expression acts as an unfavorable survival marker.
LSCC are the cancer types where ZNF548 mass-spec protein most reproducibly stratifies survival.