Across TCGA patient cohorts, ZNF548 mutation is significantly associated with the RNA expression of many other genes, with 4,207 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF548-associated genes across cancer lineages are ARHGEF7-IT1, GINS3, and KRTAP19-3. Each is linked with ZNF548 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF548-to-partner and partner-to-ZNF548 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF548→partner) and Y-score (partner→ZNF548) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	ARHGEF7-IT1 →	+0.230	+3.265	<.001	.009	3	3
UCEC	GINS3 →	+0.543	+2.606	<.001	<.001	3	3
LUAD	KRTAP19-3 →	+0.102	+4.748	<.001	.003	3	3
LUAD	SSX2B →	+0.064	+3.613	<.001	.001	3	3
UCEC	PPIL2 →	+0.312	+2.283	.001	<.001	3	3
CESC	OR6K1P →	+0.043	+4.384	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,207 associations by consensus.

Exploration

ZNF548 survival (RNA) · tumor vs normal (RNA) · all ZNF548 data types