Across TCGA patient cohorts, ZNF548 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF548-associated genes across cancer lineages are MEK1, PCNA, and STAT3_pY705. Each is linked with ZNF548 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF548-to-partner and partner-to-ZNF548 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF548→partner) and Y-score (partner→ZNF548) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.255	+1.247	.041	.045	3	3
UCEC	PCNA →	+0.215	+2.700	.003	.005	3	2
UCEC	STAT3_pY705 →	-0.333	-1.247	<.001	.045	3	2
UCEC	TFRC →	+0.378	+1.514	.036	.015	3	2
UCEC	ATM →	-0.451	-1.584	.003	.034	3	2
UCEC	EGFR_pY1068 →	-0.184	-1.807	.031	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

ZNF548 survival (RNA) · tumor vs normal (RNA) · all ZNF548 data types