Across TCGA patient cohorts, ZNF546 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF546-associated genes across cancer lineages are C-Raf, 4E-BP1, and 14-3-3_beta. Each is linked with ZNF546 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF546-to-partner and partner-to-ZNF546 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF546→partner) and Y-score (partner→ZNF546) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.130	+1.222	.005	.035	3	3
UCEC	4E-BP1 →	+0.268	+2.222	.002	.009	3	2
UCEC	14-3-3_beta →	-0.069	-1.780	.035	.024	3	2
UCEC	eIF4E →	+0.144	+1.459	.035	.012	3	2
UCEC	Notch1 →	+0.131	+1.459	.004	.012	3	2
UCEC	Shc_pY317 →	-0.134	-1.222	.006	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration

ZNF546 survival (RNA) · tumor vs normal (RNA) · all ZNF546 data types