ZNF543

Across TCGA patient cohorts, ZNF543 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF543-associated genes across cancer lineages are p70-S6K_pT389, Annexin-1, and ASNS. Each is linked with ZNF543 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF543-to-partner and partner-to-ZNF543 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K_pT389 grouped by ZNF543-low versus ZNF543-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF543→partner) and Y-score (partner→ZNF543) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K_pT389 →	-0.167	-2.459	.015	.018	3	2
UCEC	Annexin-1 →	+0.597	+2.827	.001	.001	3	2
UCEC	ASNS →	+0.404	+2.415	.001	.003	3	2
UCEC	14-3-3_beta →	-0.102	-2.673	.004	.005	3	1
UCEC	eEF2 →	+0.321	+1.874	.012	.049	3	1
UCEC	EGFR_pY1068 →	-0.305	-3.700	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

p70-S6K_pT389 by ZNF543 expression — UCEC

Explore this box plot interactively →