ZNF543

Across TCGA cell cohorts, ZNF543 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,861 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF543-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Negative regulation of gene expression, epigenetic, and Positive regulation of T-helper 17 cell lineage commitment. Each is linked with ZNF543 in more than 14 cancer types. Because this analysis shows association rather than direction, both ZNF543-to-partner and partner-to-ZNF543 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by ZNF543-low versus ZNF543-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF543→partner) and Y-score (partner→ZNF543) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Epigenetic regulation of gene expression →	+0.079	+0.541	<.001	<.001	3	15
BONE	Negative regulation of gene expression, epigenetic →	+0.076	+0.480	.001	.004	3	15
KIDNEY	Positive regulation of T-helper 17 cell lineage commitment →	+0.194	+0.525	<.001	<.001	3	15
SOFT_TISSUE	Positive regulation of mRNA metabolic process →	+0.078	+0.684	<.001	<.001	3	14
SOFT_TISSUE	Heterochromatin formation →	+0.075	+0.683	<.001	<.001	3	14
BLOOD_Lymphoma	RNA destabilization →	+0.070	+0.720	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,861 associations by consensus.

Epigenetic regulation of gene expression by ZNF543 expression — BONE

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