ZNF543

Across TCGA cell cohorts, ZNF543 mutation is significantly associated with the RNA expression of many other genes, with 182 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF543-associated genes across cancer lineages are SLC5A5, C16orf90, and GCAT. Each is linked with ZNF543 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF543-to-partner and partner-to-ZNF543 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC5A5 grouped by ZNF543-low versus ZNF543-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF543→partner) and Y-score (partner→ZNF543) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC5A5 →	+0.289	+2.546	<.001	.002	3	2
URINARY_TRACT	C16orf90 →	+0.023	+5.087	<.001	.004	3	1
LARGE_INTESTINE	GCAT →	+1.408	+3.364	<.001	.002	3	1
LARGE_INTESTINE	CBY1 →	+0.631	+3.160	.001	.006	3	1
LARGE_INTESTINE	PPM1A →	+0.532	+3.169	.001	.009	3	1
LARGE_INTESTINE	FCGRT →	-2.264	-3.169	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 182 associations by consensus.

SLC5A5 by ZNF543 expression — LARGE_INTESTINE

Explore this box plot interactively →