ZNF541

Across TCGA patient cohorts, ZNF541 mutation is significantly associated with the RNA expression of many other genes, with 3,314 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF541-associated genes across cancer lineages are LINC02340, RNA5SP412, and LIN7C. Each is linked with ZNF541 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF541-to-partner and partner-to-ZNF541 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02340 grouped by ZNF541-low versus ZNF541-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF541→partner) and Y-score (partner→ZNF541) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LINC02340 →	+0.447	+3.566	.001	.002	3	2
UCEC	RNA5SP412 →	+0.482	+1.677	<.001	.004	3	2
UCEC	LIN7C →	+0.473	+2.545	.002	<.001	3	2
UCEC	PTS →	+0.286	+3.721	.008	<.001	3	2
UCEC	TMEM263 →	+0.519	+1.934	<.001	.002	3	2
COAD	BAG3 →	+0.700	+3.499	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,314 associations by consensus.

LINC02340 by ZNF541 expression — COAD

Explore this box plot interactively →