ZNF541

Across TCGA patient cohorts, ZNF541 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF541-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with ZNF541 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF541-to-partner and partner-to-ZNF541 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZNF541-low versus ZNF541-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF541→partner) and Y-score (partner→ZNF541) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.629	-2.247	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.492	+2.019	.024	.017	3	2
UCEC	14-3-3_beta →	-0.087	-1.886	.018	.015	3	1
UCEC	EGFR_pY1068 →	-0.248	-1.847	.007	.008	3	1
UCEC	ERK2 →	+0.233	+3.584	<.001	.002	3	1
UCEC	Fibronectin →	-0.251	-1.690	.038	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

ATM by ZNF541 expression — UCEC

Explore this box plot interactively →