ZNF541

Across TCGA cell cohorts, ZNF541 mutation is significantly associated with the RNA expression of many other genes, with 743 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF541-associated genes across cancer lineages are TDRD5, LRRD1, and DAZL. Each is linked with ZNF541 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF541-to-partner and partner-to-ZNF541 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TDRD5 grouped by ZNF541-low versus ZNF541-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF541→partner) and Y-score (partner→ZNF541) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TDRD5 →	+0.641	+3.392	<.001	.005	2	3
LARGE_INTESTINE	LRRD1 →	+0.025	+2.125	.001	.009	3	2
STOMACH	DAZL →	+0.027	+4.129	.005	.007	3	2
SOFT_TISSUE	PPIAL4D →	+0.092	+3.999	.001	.004	3	1
OESOPHAGUS	OR2M3 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	OR10G2 →	+0.033	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 743 associations by consensus.

TDRD5 by ZNF541 expression — BLOOD_Leukemia

Explore this box plot interactively →