ZNF540

Across TCGA patient cohorts, ZNF540 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF540-associated genes across cancer lineages are ERK2, JNK_pT183_Y185, and MEK1. Each is linked with ZNF540 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF540-to-partner and partner-to-ZNF540 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ZNF540-low versus ZNF540-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF540→partner) and Y-score (partner→ZNF540) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.154	+1.807	.009	.024	3	2
UCEC	JNK_pT183_Y185 →	-0.156	-1.765	.002	.013	3	2
UCEC	MEK1 →	+0.375	+2.906	<.001	.001	3	2
UCEC	PCNA →	+0.194	+1.415	.003	.010	3	2
UCEC	STAT3_pY705 →	-0.375	-2.662	<.001	<.001	3	2
UCEC	TFRC →	+0.338	+1.415	.040	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ERK2 by ZNF540 expression — UCEC

Explore this box plot interactively →