ZNF540

Across TCGA cell cohorts, ZNF540 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF540-associated genes across cancer lineages are PROP1, TAS2R8, and BRDT. Each is linked with ZNF540 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF540-to-partner and partner-to-ZNF540 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROP1 grouped by ZNF540-low versus ZNF540-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF540→partner) and Y-score (partner→ZNF540) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PROP1 →	+0.020	+3.289	.001	.009	3	2
BLOOD_Leukemia	TAS2R8 →	+0.031	+3.926	<.001	.003	3	1
BLOOD_Leukemia	BRDT →	+0.127	+3.771	<.001	.004	3	1
BLOOD_Leukemia	UNC45B →	+0.233	+4.408	<.001	.001	3	1
BLOOD_Leukemia	FXYD4 →	+0.076	+4.772	.007	<.001	3	1
BLOOD_Leukemia	TDRD5 →	+0.465	+4.392	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PROP1 by ZNF540 expression — BLOOD_Leukemia

Explore this box plot interactively →