Across TCGA patient cohorts, ZNF536 mutation is significantly associated with the RNA expression of many other genes, with 11,533 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF536-associated genes across cancer lineages are EMC8, NEK2, and TOMM40. Each is linked with ZNF536 in more than 6 cancer types. Because this analysis shows association rather than direction, both ZNF536-to-partner and partner-to-ZNF536 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF536→partner) and Y-score (partner→ZNF536) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EMC8 →	+0.383	+1.943	<.001	<.001	3	7
STAD	NEK2 →	+0.665	+2.289	<.001	<.001	3	7
STAD	TOMM40 →	+0.499	+1.771	<.001	<.001	3	6
BLCA	SLC25A39 →	+0.319	+2.754	.005	.002	3	6
BLCA	TSEN34 →	+0.505	+2.343	<.001	<.001	3	6
STAD	SELP →	-0.954	-3.807	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,533 associations by consensus.

Exploration

ZNF536 survival (RNA) · tumor vs normal (RNA) · all ZNF536 data types