Across TCGA pan-cancer cohorts, ZNF534 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ZNF534’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ZNF534 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF534 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.
LUSC, KIRC, and LUAD are the cancer types where ZNF534 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF534 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.