ZNF532

Across TCGA patient cohorts, ZNF532 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF532-associated genes across cancer lineages are ATM, MEK1_p_S217_S221, and mTOR. Each is linked with ZNF532 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF532-to-partner and partner-to-ZNF532 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZNF532-low versus ZNF532-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF532→partner) and Y-score (partner→ZNF532) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.458	-1.722	<.001	<.001	3	4
COAD	MEK1_p_S217_S221 →	+0.301	+2.178	.037	.035	3	3
COAD	mTOR →	-0.199	-3.000	.040	.035	3	3
COAD	Stathmin →	+0.169	+2.178	.019	.035	3	3
UCEC	VHL →	-0.775	-1.637	<.001	.001	3	3
SKCM	c-Met_pY1235 →	+0.167	+3.321	<.001	.010	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

ATM by ZNF532 expression — UCEC

Explore this box plot interactively →