ZNF532

Across TCGA cell cohorts, ZNF532 mutation is significantly associated with the RNA expression of many other genes, with 102 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF532-associated genes across cancer lineages are CHAT, ODAM, and REG3G. Each is linked with ZNF532 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF532-to-partner and partner-to-ZNF532 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHAT grouped by ZNF532-low versus ZNF532-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF532→partner) and Y-score (partner→ZNF532) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CHAT →	+0.190	+3.874	<.001	.006	3	2
LARGE_INTESTINE	ODAM →	+1.449	+3.234	.006	.004	3	2
BLOOD_Myeloma	REG3G →	+0.053	+3.906	<.001	.009	3	1
BLOOD_Myeloma	GRM5 →	+0.135	+3.906	.006	.009	3	1
BLOOD_Myeloma	IFNL2 →	+0.040	+4.754	<.001	<.001	3	1
SOFT_TISSUE	NPVF →	+0.015	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 102 associations by consensus.

CHAT by ZNF532 expression — CNS

Explore this box plot interactively →