ZNF528

Across TCGA patient cohorts, ZNF528 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF528-associated genes across cancer lineages are PDCD4, ASNS, and Caspase-7-cleavedD198. Each is linked with ZNF528 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF528-to-partner and partner-to-ZNF528 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by ZNF528-low versus ZNF528-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF528→partner) and Y-score (partner→ZNF528) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PDCD4 →	-0.643	-2.313	<.001	.035	3	3
UCEC	ASNS →	+0.451	+3.087	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+0.892	+2.330	.012	.020	3	2
UCEC	14-3-3_beta →	-0.085	-1.738	.005	.011	3	2
UCEC	JNK2 →	+0.224	+2.222	<.001	<.001	3	2
UCEC	Notch1 →	+0.132	+1.691	.002	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

PDCD4 by ZNF528 expression — COAD

Explore this box plot interactively →