Across TCGA patient cohorts, ZNF527 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF527-associated genes across cancer lineages are PDCD4, STAT3_pY705, and ATM. Each is linked with ZNF527 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF527-to-partner and partner-to-ZNF527 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF527→partner) and Y-score (partner→ZNF527) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.437	-2.000	.008	.003	3	2
UCEC	STAT3_pY705 →	-0.442	-2.502	<.001	.001	3	2
UCEC	ATM →	-0.558	-2.000	<.001	.003	3	2
UCEC	Cyclin-B1 →	+0.688	+3.000	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.201	-1.662	.023	.011	3	1
UCEC	eIF4E →	+0.185	+3.472	.013	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

ZNF527 survival (RNA) · tumor vs normal (RNA) · all ZNF527 data types