Across TCGA cell cohorts, ZNF527 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF527-associated genes across cancer lineages are INSL5, SPINK9, and IQCF6. Each is linked with ZNF527 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF527-to-partner and partner-to-ZNF527 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF527→partner) and Y-score (partner→ZNF527) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	INSL5 →	+0.290	+3.626	<.001	.006	3	1
LARGE_INTESTINE	SPINK9 →	+0.317	+4.115	<.001	.001	3	1
LARGE_INTESTINE	IQCF6 →	+0.228	+3.882	<.001	.001	3	1
SKIN	C2CD4B →	+0.023	+3.099	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

ZNF527 survival (RNA) · tumor vs normal (RNA) · all ZNF527 data types