ZNF526

Across TCGA patient cohorts, ZNF526 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF526-associated genes across cancer lineages are TFRC, eIF4E, and Heregulin. Each is linked with ZNF526 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF526-to-partner and partner-to-ZNF526 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by ZNF526-low versus ZNF526-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF526→partner) and Y-score (partner→ZNF526) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.528	+2.459	.007	.018	3	2
UCEC	eIF4E →	+0.177	+3.183	.025	.009	3	1
UCEC	Heregulin →	-0.116	-1.765	.012	.014	3	1
UCEC	IGFBP2 →	-0.984	-2.662	<.001	<.001	3	1
UCEC	Ku80 →	+0.256	+2.710	.003	.003	3	1
UCEC	MEK1 →	+0.442	+3.000	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

TFRC by ZNF526 expression — UCEC

Explore this box plot interactively →