ZNF526

Across TCGA cell cohorts, ZNF526 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,759 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF526-associated GO terms across cancer lineages are Negative regulation of calcium ion export across plasma membrane, Protein destabilization, and Heterochromatin formation. Each is linked with ZNF526 in more than 13 cancer types. Because this analysis shows association rather than direction, both ZNF526-to-partner and partner-to-ZNF526 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion export across plasma membrane grouped by ZNF526-low versus ZNF526-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF526→partner) and Y-score (partner→ZNF526) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.072	+0.539	<.001	<.001	3	14
STOMACH	Protein destabilization →	+0.112	+0.996	.004	<.001	3	14
BONE	Heterochromatin formation →	+0.096	+0.836	<.001	<.001	3	14
BONE	Metaphase/anaphase transition of cell cycle →	+0.162	+0.652	<.001	<.001	3	13
BONE	Metaphase/anaphase transition of mitotic cell cycle →	+0.160	+0.599	<.001	<.001	3	13
OESOPHAGUS	Phosphatidylinositol biosynthetic process →	+0.070	+0.871	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,759 associations by consensus.

Negative regulation of calcium ion export across plasma membrane by ZNF526 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →