ZNF526

Across TCGA cell cohorts, ZNF526 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF526-associated genes across cancer lineages are OR2D3, OR52R1, and HHLA1. Each is linked with ZNF526 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF526-to-partner and partner-to-ZNF526 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2D3 grouped by ZNF526-low versus ZNF526-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF526→partner) and Y-score (partner→ZNF526) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	OR2D3 →	+0.133	+5.169	<.001	.004	3	1
BONE	OR52R1 →	+0.046	+5.169	<.001	.004	3	1
BLOOD_Leukemia	HHLA1 →	+0.009	+3.551	<.001	.009	3	1
BLOOD_Leukemia	TACR3 →	+0.034	+4.060	<.001	.003	3	1
BLOOD_Leukemia	OR1N1 →	+0.064	+4.234	<.001	.003	3	1
BLOOD_Leukemia	PRND →	+0.009	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

OR2D3 by ZNF526 expression — BONE

Explore this box plot interactively →