Across TCGA patient cohorts, ZNF521 protein abundance is significantly associated with the protein abundance of many other proteins, with 14,022 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ZNF521-associated proteins across cancer lineages are ZNF521_S273, ZNF521_S546, and LIX1L. Each is linked with ZNF521 in more than 5 cancer types. Because this analysis shows association rather than direction, both ZNF521-to-partner and partner-to-ZNF521 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF521→partner) and Y-score (partner→ZNF521) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZNF521_S273 →	+1.126	+1.167	<.001	<.001	3	6
HNSC	ZNF521_S546 →	+1.068	+0.921	<.001	.002	3	6
UCEC	LIX1L →	+0.429	+0.735	<.001	.001	3	5
LSCC	MRC2 →	+0.804	+0.701	<.001	<.001	3	5
LSCC	DAP3 →	-0.508	-0.581	<.001	<.001	3	5
UCEC	SGCD →	+0.854	+0.966	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,022 associations by consensus.

Exploration

ZNF521 survival (RNA) · tumor vs normal (RNA) · all ZNF521 data types