Across TCGA patient cohorts, ZNF521 mutation is significantly associated with the RNA expression of many other genes, with 4,560 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF521-associated genes across cancer lineages are CSPG5, TYMS, and MRPL57. Each is linked with ZNF521 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF521-to-partner and partner-to-ZNF521 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF521→partner) and Y-score (partner→ZNF521) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CSPG5 →	+0.614	+1.220	<.001	.002	3	4
UCEC	TYMS →	+0.616	+1.478	<.001	<.001	3	4
SKCM	MRPL57 →	+0.333	+2.044	.002	.005	3	4
UCEC	NEIL3 →	+0.374	+1.546	.002	.002	3	4
UCEC	AUP1 →	+0.229	+2.091	<.001	<.001	3	4
UCEC	WRAP73 →	+0.303	+1.759	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,560 associations by consensus.

Exploration

ZNF521 survival (RNA) · tumor vs normal (RNA) · all ZNF521 data types