Across TCGA patient cohorts, ZNF521 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF521-associated genes across cancer lineages are MSH6, 14-3-3_epsilon, and PCNA. Each is linked with ZNF521 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF521-to-partner and partner-to-ZNF521 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF521→partner) and Y-score (partner→ZNF521) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MSH6 →	+0.210	+1.502	.027	.030	3	3
LUAD	14-3-3_epsilon →	+0.069	+1.498	.040	.032	3	3
UCEC	PCNA →	+0.175	+2.087	.003	.004	3	3
LUAD	Cyclin-E2 →	+0.097	+1.891	.024	.001	3	3
CESC	Caspase-7-cleavedD198 →	+0.769	+3.169	.003	.017	2	4
COAD	EGFR_pY1068 →	-0.390	-3.169	.001	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Exploration

ZNF521 survival (RNA) · tumor vs normal (RNA) · all ZNF521 data types