Across TCGA cell cohorts, ZNF521 mutation is significantly associated with the RNA expression of many other genes, with 374 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF521-associated genes across cancer lineages are KLHL40, EPPIN, and KCNJ10. Each is linked with ZNF521 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF521-to-partner and partner-to-ZNF521 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF521→partner) and Y-score (partner→ZNF521) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	KLHL40 →	+0.015	+3.870	<.001	.003	3	3
BLOOD_Lymphoma	EPPIN →	+0.033	+2.544	<.001	.007	3	2
BLOOD_Lymphoma	KCNJ10 →	+0.345	+3.243	<.001	.006	3	2
UPPER_AERODIGESTIVE_TRACT	CNGA3 →	+0.045	+4.491	<.001	.002	3	2
UPPER_AERODIGESTIVE_TRACT	MS4A10 →	+0.013	+3.510	<.001	.007	3	2
LARGE_INTESTINE	DCTN4 →	+0.446	+2.588	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 374 associations by consensus.

Exploration

ZNF521 survival (RNA) · tumor vs normal (RNA) · all ZNF521 data types