Across TCGA pan-cancer cohorts, ZNF519P1 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of ZNF519P1’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ZNF519P1 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF519P1 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
LUSC are the cancer types where ZNF519P1 tumor–normal differential expression is most reproducible.