ZNF518B

Across TCGA patient cohorts, ZNF518B mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF518B-associated genes across cancer lineages are ATM, EGFR_pY1068, and mTOR_pS2448. Each is linked with ZNF518B in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF518B-to-partner and partner-to-ZNF518B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZNF518B-low versus ZNF518B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF518B→partner) and Y-score (partner→ZNF518B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.480	-2.571	<.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.231	-1.836	<.001	.001	3	2
UCEC	mTOR_pS2448 →	-0.094	-1.439	.021	.011	3	2
UCEC	Notch1 →	+0.150	+1.540	<.001	.001	3	2
UCEC	Annexin-1 →	+0.387	+1.221	.007	.016	3	2
UCEC	Caspase-7-cleavedD198 →	+0.426	+1.543	.009	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

ATM by ZNF518B expression — UCEC

Explore this box plot interactively →