ZNF516

Across TCGA pan-cancer cohorts, ZNF516 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ZNF516 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ZNF516 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF516 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

CCRCC, HNSC, and UCEC are the cancer types where ZNF516 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	II,III,IV	0.688	1.000	<.001	20	view →
HNSC	DFS	Quartile	III,IV	0.714	0.973	.007	19	view →
UCEC	DFS	Tertile	III,IV	0.239	0.848	.030	4	view →
PDAC	OS	Tertile	All	0.406	0.647	.039	4	view →
LSCC	OS	Tertile	All	1.000	0.936	.039	3	view →
LUAD	OS	Tertile	II,III,IV	0.927	0.507	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ZNF516–CCRCC (OS)

Open the CCRCC breakdown →