ZNF516

Across TCGA patient cohorts, ZNF516 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF516-associated genes across cancer lineages are FOXO3a_pS318_S321, Stathmin, and C-Raf_pS338. Each is linked with ZNF516 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF516-to-partner and partner-to-ZNF516 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by ZNF516-low versus ZNF516-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF516→partner) and Y-score (partner→ZNF516) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.093	-1.668	.031	.021	3	3
UCEC	Stathmin →	+0.109	+1.736	.022	.007	3	3
UCEC	C-Raf_pS338 →	-0.078	-1.440	.006	.024	3	3
UCEC	Cyclin-B1 →	+0.664	+2.070	<.001	.001	3	3
COAD	FASN →	+0.349	+2.815	.022	.001	3	3
UCEC	FoxM1 →	+0.211	+2.125	.018	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

FOXO3a_pS318_S321 by ZNF516 expression — UCEC

Explore this box plot interactively →