ZNF516

Across TCGA cell cohorts, ZNF516 mutation is significantly associated with the RNA expression of many other genes, with 1,105 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF516-associated genes across cancer lineages are AVP, OR6V1, and NPHS2. Each is linked with ZNF516 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF516-to-partner and partner-to-ZNF516 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by ZNF516-low versus ZNF516-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF516→partner) and Y-score (partner→ZNF516) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	AVP →	+0.071	+4.108	<.001	.005	3	2
LUNG_NSCLC_LUSC	OR6V1 →	+0.072	+4.584	<.001	.001	3	2
URINARY_TRACT	NPHS2 →	+0.150	+4.044	.001	.001	3	2
URINARY_TRACT	DNASE2B →	+0.211	+3.584	.004	.009	3	2
BLOOD_Leukemia	HMHB1 →	+1.803	+2.882	.005	.006	3	2
LARGE_INTESTINE	ZIC5 →	+1.083	+2.364	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,105 associations by consensus.

AVP by ZNF516 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →