ZNF514

Across TCGA patient cohorts, ZNF514 mutation is significantly associated with the RNA expression of many other genes, with 1,782 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF514-associated genes across cancer lineages are SLC35B1, MIR8053, and SEC13. Each is linked with ZNF514 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF514-to-partner and partner-to-ZNF514 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC35B1 grouped by ZNF514-low versus ZNF514-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF514→partner) and Y-score (partner→ZNF514) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SLC35B1 →	+0.389	+3.706	.004	<.001	3	2
COAD	MIR8053 →	+0.261	+4.399	<.001	.006	3	2
UCEC	SEC13 →	+0.393	+2.947	<.001	<.001	3	2
UCEC	DEDD2 →	+0.359	+3.016	.002	<.001	3	2
UCEC	PPP1R36 →	-0.496	-1.847	.006	.009	3	2
UCEC	CDC34 →	+0.378	+2.246	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,782 associations by consensus.

SLC35B1 by ZNF514 expression — SKCM

Explore this box plot interactively →