ZNF514

Across TCGA patient cohorts, ZNF514 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF514-associated genes across cancer lineages are BRD4, Caspase-7-cleavedD198, and eIF4E. Each is linked with ZNF514 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF514-to-partner and partner-to-ZNF514 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRD4 grouped by ZNF514-low versus ZNF514-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF514→partner) and Y-score (partner→ZNF514) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BRD4 →	+0.256	+2.999	.020	.034	3	2
UCEC	Caspase-7-cleavedD198 →	+0.770	+1.906	.001	.016	3	2
UCEC	eIF4E →	+0.214	+3.183	.011	.009	3	1
UCEC	A-Raf_pS299 →	-0.157	-3.169	.001	.019	3	1
UCEC	ERK2 →	+0.279	+2.906	<.001	.001	3	1
UCEC	FoxM1 →	+0.207	+1.906	.047	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

BRD4 by ZNF514 expression — UCEC

Explore this box plot interactively →