ZNF512

Across TCGA pan-cancer cohorts, ZNF512 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated ZNF512 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF512 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF512 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

HNSC, COAD, and PDAC are the cancer types where ZNF512 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.625	0.949	.001	42	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.910	.043	18	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	17	view →
CCRCC	DFS	Median	II,III,IV	0.482	1.000	.027	5	view →
OV	DFS	Median	All	0.715	1.000	.046	4	view →
UCEC	OS	Quartile	II,III,IV	1.000	0.430	.045	4	view →
LUAD	OS	Quartile	III,IV	0.364	0.801	.012	3	view →
LSCC	DFS	Median	II,III,IV	0.999	0.830	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

ZNF512–HNSC (DFS)

Open the HNSC breakdown →