ZNF510

Across TCGA patient cohorts, ZNF510 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF510-associated genes across cancer lineages are eIF4E, Ku80, and MEK1. Each is linked with ZNF510 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF510-to-partner and partner-to-ZNF510 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZNF510-low versus ZNF510-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF510→partner) and Y-score (partner→ZNF510) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.169	+3.335	.020	.005	3	2
UCEC	Ku80 →	+0.220	+1.750	.007	.004	3	2
UCEC	MEK1 →	+0.313	+1.906	.013	.015	3	2
UCEC	MSH2 →	-0.317	-2.295	<.001	.005	3	2
UCEC	mTOR_pS2448 →	-0.127	-1.794	.014	.024	3	2
UCEC	Caspase-7-cleavedD198 →	+0.620	+2.341	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

eIF4E by ZNF510 expression — UCEC

Explore this box plot interactively →