ZNF506

Across TCGA pan-cancer cohorts, ZNF506 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of ZNF506’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ZNF506 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF506 is over-expressed in tumor, although a few such as LSCC show the opposite, repressed pattern.

LUAD and LSCC are the cancer types where ZNF506 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF506 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+0.606	.002	5	view →
LSCC	All	All	−0.264	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

ZNF506–LUAD

Open the LUAD breakdown →