ZNF506

Across TCGA patient cohorts, ZNF506 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF506-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and INPP4B. Each is linked with ZNF506 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF506-to-partner and partner-to-ZNF506 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZNF506-low versus ZNF506-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF506→partner) and Y-score (partner→ZNF506) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.226	+3.700	.021	.001	3	1
UCEC	A-Raf_pS299 →	-0.179	-3.000	.001	.036	3	1
UCEC	INPP4B →	-0.317	-2.999	.035	.035	3	1
UCEC	ACVRL1 →	-0.174	-2.302	.006	.034	3	1
UCEC	JNK2 →	+0.231	+2.584	.012	.011	3	1
UCEC	MEK1 →	+0.549	+3.700	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

eIF4E by ZNF506 expression — UCEC

Explore this box plot interactively →