ZNF500

Across TCGA patient cohorts, ZNF500 mutation is significantly associated with the RNA expression of many other genes, with 1,287 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF500-associated genes across cancer lineages are SEMA4G, DPP3P1, and RN7SL545P. Each is linked with ZNF500 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF500-to-partner and partner-to-ZNF500 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMA4G grouped by ZNF500-low versus ZNF500-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF500→partner) and Y-score (partner→ZNF500) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEMA4G →	+0.720	+2.906	.002	.002	3	2
LUAD	DPP3P1 →	+0.029	+4.453	.002	.006	3	2
LUAD	RN7SL545P →	+0.113	+6.333	<.001	<.001	3	2
UCEC	JOSD1 →	+0.539	+2.906	.001	.002	3	2
UCEC	SUN2 →	+0.570	+3.475	.008	.002	3	2
UCEC	MIR337 →	+0.110	+4.571	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,287 associations by consensus.

SEMA4G by ZNF500 expression — UCEC

Explore this box plot interactively →