ZNF500

Across TCGA cell cohorts, ZNF500 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible ZNF500-associated genes across cancer lineages are STRA8, ACSM2A, and MRAP. Each is linked with ZNF500 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF500-to-partner and partner-to-ZNF500 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STRA8 grouped by ZNF500-low versus ZNF500-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF500→partner) and Y-score (partner→ZNF500) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	STRA8 →	+0.012	+5.000	.002	.006	3	1
PANCREAS	ACSM2A →	+0.033	+5.000	<.001	.006	3	1
BREAST	MRAP →	+0.047	+4.672	.001	.002	3	1
BREAST	CD209 →	+0.006	+4.421	<.001	.004	3	1
SKIN	AVP →	+0.017	+3.700	<.001	.009	3	1
SKIN	OR10G3 →	+0.002	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

STRA8 by ZNF500 expression — PANCREAS

Explore this box plot interactively →