ZNF497

Across TCGA pan-cancer cohorts, ZNF497 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ZNF497 data layer compared with 30 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ZNF497 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF497 expression acts as an unfavorable survival marker.

LUAD, STAD, and LUSC are the cancer types where ZNF497 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.057	0.788	<.001	24	view →
STAD	DFS	Median	III,IV	0.248	0.596	.009	12	view →
LUSC	DFS	Median	II,III,IV	0.199	0.748	.006	6	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	OS	Median	III,IV	0.233	0.705	.034	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ZNF497–LUAD (OS)

Open the LUAD breakdown →