ZNF497

Across TCGA patient cohorts, ZNF497 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF497-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and ERK2. Each is linked with ZNF497 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF497-to-partner and partner-to-ZNF497 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZNF497-low versus ZNF497-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF497→partner) and Y-score (partner→ZNF497) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.182	+3.335	.032	.005	3	1
UCEC	A-Raf_pS299 →	-0.178	-2.000	<.001	.030	3	1
UCEC	ERK2 →	+0.204	+1.906	.008	.016	3	1
UCEC	GSK-3_pS9 →	+0.340	+1.906	.036	.016	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.515	+2.700	.002	.005	3	1
UCEC	Ku80 →	+0.315	+2.428	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

eIF4E by ZNF497 expression — UCEC

Explore this box plot interactively →