ZNF497

Across TCGA cell cohorts, ZNF497 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF497-associated genes across cancer lineages are C16orf92, KRTAP10-5, and BHLHA9. Each is linked with ZNF497 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF497-to-partner and partner-to-ZNF497 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf92 grouped by ZNF497-low versus ZNF497-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF497→partner) and Y-score (partner→ZNF497) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C16orf92 →	+0.176	+3.622	<.001	<.001	3	2
LUNG_NSCLC_LUAD	KRTAP10-5 →	+0.019	+5.662	<.001	.002	3	1
UPPER_AERODIGESTIVE_TRACT	BHLHA9 →	+0.017	+4.357	<.001	.006	3	1
LARGE_INTESTINE	AVP →	+0.048	+3.217	<.001	.006	3	1
LARGE_INTESTINE	MOGAT1 →	+0.159	+2.878	<.001	.009	3	1
LARGE_INTESTINE	PLVAP →	+0.226	+3.426	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

C16orf92 by ZNF497 expression — BLOOD_Leukemia

Explore this box plot interactively →