ZNF496

Across TCGA patient cohorts, ZNF496 mutation is significantly associated with the RNA expression of many other genes, with 3,592 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF496-associated genes across cancer lineages are RN7SL55P, POLH-AS1, and PLA2G12AP1. Each is linked with ZNF496 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF496-to-partner and partner-to-ZNF496 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL55P grouped by ZNF496-low versus ZNF496-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF496→partner) and Y-score (partner→ZNF496) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RN7SL55P →	+0.209	+5.149	<.001	.007	3	3
UCEC	POLH-AS1 →	+0.630	+1.906	<.001	<.001	3	3
UCEC	PLA2G12AP1 →	+0.330	+2.202	<.001	.001	3	3
UCEC	HPGDS →	-0.393	-2.662	<.001	<.001	3	3
UCEC	POC1A →	+0.449	+2.584	.003	<.001	3	3
UCEC	PBK →	+0.814	+2.425	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,592 associations by consensus.

RN7SL55P by ZNF496 expression — GBM

Explore this box plot interactively →