ZNF496

Across TCGA patient cohorts, ZNF496 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF496-associated genes across cancer lineages are Cyclin-B1, 14-3-3_beta, and eEF2. Each is linked with ZNF496 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF496-to-partner and partner-to-ZNF496 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ZNF496-low versus ZNF496-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF496→partner) and Y-score (partner→ZNF496) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.568	+1.523	.001	.008	3	4
UCEC	14-3-3_beta →	-0.104	-2.880	.001	.001	3	2
UCEC	eEF2 →	+0.422	+2.058	<.001	<.001	3	2
UCEC	INPP4B →	-0.205	-1.906	.047	.014	3	2
UCEC	N-Ras →	-0.096	-1.276	.011	.023	3	2
UCEC	PDCD4 →	-0.491	-1.523	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Cyclin-B1 by ZNF496 expression — UCEC

Explore this box plot interactively →