Across TCGA patient cohorts, ZNF493 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF493-associated genes across cancer lineages are Caspase-8, 4E-BP1, and JNK_pT183_Y185. Each is linked with ZNF493 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF493-to-partner and partner-to-ZNF493 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF493→partner) and Y-score (partner→ZNF493) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.253	-3.089	<.001	<.001	3	4
UCEC	4E-BP1 →	+0.292	+1.968	<.001	<.001	3	4
COAD	JNK_pT183_Y185 →	-0.236	-3.000	.036	.035	3	3
COAD	PCNA →	+0.234	+2.467	.029	.011	3	3
COAD	eEF2 →	+0.377	+2.467	.003	.011	3	2
LUSC	4E-BP1_pT37_T46 →	-0.652	-2.990	.019	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Exploration

ZNF493 survival (RNA) · tumor vs normal (RNA) · all ZNF493 data types