ZNF492

Across TCGA patient cohorts, ZNF492 mutation is significantly associated with the RNA expression of many other genes, with 3,379 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF492-associated genes across cancer lineages are RAD51C, CENPO, and LARP1B. Each is linked with ZNF492 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF492-to-partner and partner-to-ZNF492 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51C grouped by ZNF492-low versus ZNF492-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF492→partner) and Y-score (partner→ZNF492) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RAD51C →	+0.508	+2.735	<.001	.003	3	4
UCEC	CENPO →	+0.499	+2.021	<.001	<.001	3	4
UCEC	LARP1B →	+0.507	+2.053	<.001	<.001	3	4
UCEC	COX11 →	+0.377	+2.343	.004	<.001	3	4
UCEC	CKAP2L →	+0.524	+2.761	.005	<.001	3	4
UCEC	MTHFD2 →	+0.645	+1.864	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,379 associations by consensus.

RAD51C by ZNF492 expression — LUSC

Explore this box plot interactively →